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A variety of health care providers are located throughout the Upstate. While there are many individual doctor’s offices and urgent care facilities, Prisma, Bon Secours St. Francis Health Care System, AnMed and Spartanburg Regional Healthcare System serve as four of the largest health care systems in the area. These providers also run a majority of the Upstate’s hospitals, and a variety of practices exist under their umbrellas.
| Health system | Counties with hospitals | Number of hospitals | Number of employees | Number of patients served in 2021 | Specialty practices |
| Bon Secours St. Francis Health System | Greenville | 2 | 4,201 | 110,237 | Oncology
Neurology Cardiology Orthopedics Bariatrics General surgery |
| Prisma | Greenville
Oconee Pickens Laurens |
11 | 28,761 | 1.5 million unique patients treated across Prisma’s network (Oct. 1, 2020-Sept. 30, 2021) | Cancer care
Cardiovascular care Orthopedics OB/GYN Transplant Center |
| Spartanburg Regional Healthcare System | Spartanburg
Cherokee Union |
6 | 9,500 | More than 200,000 emergency center visits
More than 25,000 surgical procedures More than 4,000 babies delivered |
Cancer care
Breast health Level I Trauma Center Heart Center Orthopedic services |
| AnMed | Anderson | 4 | 3,705 | More than 1.02 million | Heart/vascular
Oncology Orthopedic Primary care |
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