A locust’s brain has been hacked to sniff out human cancer

In all cases, the animals are thought to be sensing chemicals that people emit through body odor or breath. The mix of chemicals can vary depending on a person’s metabolism, which is thought to change when we get sick. But dogs are expensive to train and look after. And making a device that mimics a dog’s nose has proved extremely difficult to do, says Debajit Saha, one of the scientists behind the latest work, which has not yet been peer-reviewed.

“These changes are almost in parts per trillion,” says Saha, a neural engineer at Michigan State University. This makes them hard to pick up even with state-of-the-art technologies, he adds. But animals have evolved to interpret such subtle changes in scents. So he and his colleagues decided to “hijack” an animal brain instead.

COURTESY OF THE RESEARCHERS

The researchers chose to work with locusts because these insects have been well studied in recent years. In a preliminary setup, they surgically exposed the brain of a living locust. Saha and his colleagues then inserted electrodes into the lobes of the brain that receive signals from the insects’ antennae, which they use to sense odors.

The team also grew three different types of human oral cancer cells, as well as human mouth cells that were cancer-free. They used a device to capture gas emitted by each of the cell types, and delivered each of these to the locusts’ antennae.

The locusts’ brains responded to each of the cell types differently. The patterns of electrical activity recorded were so distinct that when the team puffed the gas from one cell type onto the antennae, they could correctly identify whether the cells were cancerous from the recording alone.

It is the first time a living insect brain has been tested as a tool to detect cancer, says Saha.

Natalie Plank, who is developing nanomaterial-based health sensors at Victoria University of Wellington in New Zealand, thinks the work is “super cool.” “The potential of just being able to breathe on something and then know if you’re at risk for cancer… is really powerful,” she says.

In the experiment, the team took brain recordings from multiple locusts and combined their responses. It currently takes recordings from 40 neurons to get a clear signal, which means the system requires between six and 10 locust brains. But Saha hopes to use electrodes that can record from more neurons, which would allow him to get recordings from the brain of a single locust. He also hopes to be able to use the brain and antennae in a portable device, which could then be tested on real people.